Dr. Masaya Yamamoto Current research focuses on uncovering the active roles of astrocytes in regulating synaptic plasticity, learning, and memory, using an integrated, multi-scale approach that combines molecular analysis, in vivo imaging, and spatiotemporal proteomics. Recent work has clarified how astrocytic calcium microdomains, gliotransmitter release, and multisynaptic compartmental signaling coordinate to influence neuronal circuit dynamics. Advanced proteomic profiling is being applied to map activity-dependent changes in astrocyte–neuron communication, revealing novel regulatory proteins and pathways involved in cognitive processing and synaptic remodeling. In vivo imaging techniques are used to track astrocyte and neuronal interactions in real time during learning phases, providing functional insight into the temporal dynamics of memory consolidation. This research reframes astrocytes as essential, active participants in information processing rather than passive support cells. In the context of neurodegeneration, ongoing studies investigate how astrocytic dysfunction contributes to impaired synaptic communication and cognitive decline, offering potential molecular targets for intervention in disorders such as Alzheimer’s disease and vascular dementia. By bridging molecular neuroscience, systems biology, and computational interpretation, this work advances understanding of glial pathology and proposes innovative mechanisms through which astrocytes shape network plasticity and cognitive resilience, contributing significantly to emerging models of brain function and neurological disease progression.